DEPARTMENT OF BIOSTATISTICS AND BIOINFORMATICS SEMINAR
On the Analysis of Clustered Semi-Competing Risks Data
Presented By
Abstract:
To monitor quality of care in the US, the Centers for Medicare and Medicaid Services (CMS) currently reports, among other measures, hospital-specific 30-day readmission rates, estimated on the basis of a logistic-Normal GLMM. The focus of these efforts is on health conditions with low mortality, including pneumonia and heart failure. Expanding these efforts to include a broad range of increasingly prevalent ‘advanced’ health conditions, such as Alzheimer’s disease and cancer, is problematic because the current CMS approach ignores death as a truncating event. A more appropriate analysis would be to frame quality of care assessments within the semi-competing risk framework although, to our knowledge, no statistical methods for clustered semi-competing risks data have been developed. We propose a novel semi-parametric hierarchical model for clustered semi-competing data based on an illness-death model. Estimation and inference is within the Bayesian paradigm, which facilitates the use of hospital-specific shrinkage targets and flexible random effects distributions. An efficient computational algorithm is developed, based on the Metropolis-Hastings-Green algorithm. The proposed framework is then applied to data on all individuals diagnosed with pancreatic cancer between 2005-2008 from Medicare Part A.
Parking available in the Michael Street Visitor parking
deck (behind Wayne Rollins Research Building...2nd deck entrance) or at the
1525 Clifton Road Visitor pay parking deck (building directly across the
street from Grace Crum Rollins Building).
Please visit our webpage at:
http://www.sph.emory.edu/departments_centers/bios/index.html
Questions: rwaggon@emory.edu