Our statistical methodology research and collaborations focus on various biomedical imaging areas. Primarily, we work with brain imaging data, including both functional and structural neuroimaging modalities. We have also worked in cardiac imaging and in cancer applications, including brain tumor, breast and prostate cancer imaging.
Generally, functional neuroimaging is a method for mapping measures of localized brain activity in vivo. We apply our methods to functional neuroimaging applications that seek to characterize changes in distributed neural processing associated with psychiatric disorders, drug cravings, behaviors, emotions, and decision-making. CBIS also conducts research on brain networks and functional connectivity, which provides insights into the relationships between different brain regions when performing a particular task or during resting state. In recent years, the collection of multimodal neuroimaging (fMRI, sMRI and DTI, etc.) has become common practice to provide different views of brain function or structure. CBIS has been working on developing effective analytical tools for fusing multimodal imaging to obtain more accurate and informative results on brain function and connectivity.
Our research seeks state-of-the-art biostatistical methods that are applicable (1) to describe functional associations between brain regions, (2) to determine functional connectivity and hierarchical networks in the brain, (3) to make inferences concerning task-related changes in brain activity that ultimately produce maps revealing distributed patterns of task/activity associations, (4) to address various prediction objectives and (5) to conduct integrative analysis of multimodal imaging data. Specifically, we have applied our statistical methods to help better understand the neural correlates underlying.
brain disorders such as depression, PTSD, Alzheimer’s disease, and schizophrenia
task-related and resting-state functional connectivity differences in Zen meditators
social anxiety disorder and its response to pharmacotherapy
the sensitivity to ethical issues related to justice and care
cue-induced nicotine craving
We briefly describe our statistical methodology research below…